Karen Smith Selected Research

Tenecteplase

1/2023	Cost-effectiveness of tenecteplase versus alteplase for stroke thrombolysis evaluation trial in the ambulance.
1/2022	Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (Mobile Stroke Unit-TASTE-A): protocol for a prospective randomised, open-label, blinded endpoint, phase II superiority trial of tenecteplase versus alteplase for ischaemic stroke patients presenting within 4.5 hours of symptom onset to the mobile stroke unit.
1/2022	Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial.

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Karen Smith Research Topics

Disease

53	Out-of-Hospital Cardiac Arrest 01/2024 - 02/2002
29	Heart Arrest (Cardiac Arrest) 03/2024 - 01/2003
20	Wounds and Injuries (Trauma) 01/2024 - 04/2007
16	ST Elevation Myocardial Infarction 04/2024 - 03/2012
15	Pain (Aches) 05/2024 - 05/2013
11	Myocardial Infarction 06/2023 - 03/2012
11	Chest Pain (Chest Pains) 02/2023 - 12/2002
11	Stroke (Strokes) 01/2023 - 01/2017
11	Neoplasms (Cancer) 01/2022 - 05/2006
10	Infections 01/2023 - 08/2008
9	Acute Coronary Syndrome 02/2023 - 12/2012
7	Idiopathic Pulmonary Fibrosis 01/2023 - 07/2012
7	Huntington Disease (Huntington's Disease) 10/2011 - 10/2003
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2024 - 12/2012
5	Hemorrhage 11/2023 - 01/2012
5	COVID-19 03/2023 - 01/2021
5	Ischemic Stroke 01/2023 - 01/2021
5	Infarction (Infarctions) 12/2021 - 03/2016
5	Fibrosis (Cirrhosis) 03/2019 - 05/2009
5	Atrophy 01/2018 - 08/2007
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/2013 - 06/2005
4	Shock 12/2023 - 03/2014
4	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2023 - 01/2012
4	Spinal Cord Injuries (Spinal Cord Injury) 01/2023 - 11/2016
4	Myocardial Ischemia (Ischemic Heart Diseases) 09/2022 - 07/2015
4	Body Weight (Weight, Body) 07/2022 - 10/2003
4	Coma (Comas) 01/2019 - 02/2002
4	Breast Neoplasms (Breast Cancer) 02/2015 - 08/2005
3	Urinary Tract Infections (Urinary Tract Infection) 01/2023 - 01/2021
3	Hypoxia (Hypoxemia) 01/2023 - 03/2012
3	Cardiogenic Shock 10/2022 - 03/2016
3	Seizures (Absence Seizure) 08/2022 - 09/2018
3	Ulcer 06/2021 - 03/2016
3	Ventricular Fibrillation 06/2021 - 08/2010
3	Asthma (Bronchial Asthma) 12/2017 - 06/2004
3	Hypothermia 01/2015 - 02/2002
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2012 - 03/2008
2	Cognitive Dysfunction 11/2023 - 06/2021
2	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2020
2	Spasm (Spasms) 01/2023 - 05/2020
2	Surgical Wound 10/2022 - 01/2008
2	Ischemia 09/2022 - 07/2008
2	Ventilator-Associated Pneumonia 01/2022 - 01/2018

Drug/Important Bio-Agent (IBA)

12	Opioid Analgesics (Opioids)IBA 02/2023 - 01/2015
9	Oxygen (Dioxygen)IBA 11/2022 - 03/2012
8	Biomarkers (Surrogate Marker)IBA 01/2023 - 07/2010
8	Anti-Bacterial Agents (Antibiotics)IBA 12/2022 - 11/2004
5	Fentanyl (Sublimaze)FDA LinkGeneric 01/2023 - 01/2019
5	TroponinIBA 01/2023 - 02/2004
5	Proteins (Proteins, Gene)FDA Link 09/2022 - 05/2006
5	Morphine (MS Contin)FDA LinkGeneric 01/2022 - 01/2019
5	Analgesics (Analgesic Drugs)IBA 01/2022 - 06/2016
4	Creatine Kinase (Creatine Phosphokinase)IBA 12/2021 - 07/2010
4	Epinephrine (Adrenaline)FDA LinkGeneric 11/2021 - 04/2014
4	Heroin (Diamorphine)IBA 01/2021 - 09/2018
4	IceIBA 01/2015 - 01/2003
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/2023 - 02/2004
3	omega-Chloroacetophenone (Mace)IBA 02/2023 - 07/2008
3	Lidocaine (Xylocaine)FDA LinkGeneric 01/2023 - 01/2021
3	Troponin IIBA 01/2023 - 06/2015
3	Tenecteplase FDA Link 01/2023 - 01/2022
3	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2023 - 01/2022
3	C-Reactive ProteinIBA 07/2022 - 06/2013
3	insulin receptor-related receptor (IRR)IBA 07/2021 - 01/2016
3	Antidepressive Agents (Antidepressants)IBA 12/2020 - 03/2008
3	MicroRNAs (MicroRNA)IBA 01/2018 - 07/2007
3	Histone Deacetylases (Histone Deacetylase)IBA 09/2015 - 10/2003
3	Eukaryotic Initiation Factor-4EIBA 02/2015 - 07/2007
3	CaspasesIBA 07/2013 - 06/2005
2	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 07/2022
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2024 - 01/2023
2	Tranexamic Acid (AMCA)FDA Link 11/2023 - 04/2014
2	Antifibrinolytic Agents (Antifibrinolytics)IBA 11/2023 - 04/2014
2	Interleukin-8 (Interleukin 8)IBA 01/2023 - 01/2018
2	Illicit Drugs (Recreational Drugs)IBA 01/2023 - 01/2022
2	Adenosine Triphosphate (ATP)IBA 09/2022 - 12/2010
2	LipidsIBA 07/2022 - 10/2004
2	AnticoagulantsIBA 01/2022 - 01/2012

Therapy/Procedure

36	Resuscitation 01/2023 - 02/2002
28	Cardiopulmonary Resuscitation (CPR) 01/2024 - 10/2011
21	Therapeutics 07/2023 - 07/2005
11	Percutaneous Coronary Intervention 04/2024 - 03/2012
9	Drug Therapy (Chemotherapy) 01/2022 - 10/2003
8	Analgesia 02/2023 - 11/2015
7	Thrombectomy 01/2023 - 01/2017
7	Critical Care (Surgical Intensive Care) 06/2022 - 01/2008
7	Induced Hypothermia 09/2016 - 02/2002
5	Defibrillators (Defibrillator) 12/2023 - 12/2016
5	Thoracostomy 11/2021 - 01/2019
5	Cardiac Rehabilitation 01/2019 - 12/2012
4	Length of Stay 06/2023 - 05/2018
3	Artificial Respiration (Mechanical Ventilation) 01/2022 - 01/2008
3	Aftercare (After-Treatment) 09/2021 - 06/2004
3	Electric Countershock (Cardioversion) 06/2021 - 07/2017
3	Catheters 01/2021 - 01/2020
2	Treatment Delay 04/2024 - 01/2022
2	Palliative Care (Palliative Therapy) 03/2024 - 01/2019
2	Polypharmacy 01/2023 - 06/2021
2	Pain Management 12/2022 - 11/2015
2	Airway Management 08/2022 - 05/2018